ALDOB (aldolase B, fructose-bisphosphate)
نویسندگان
چکیده
Other names: ALDB, EC 4.1.2.13, OTTHUMP00000021803 HGNC (Hugo): ALDOB Location: 9q31.1 Local order: Telomeric to the PRG-3 (plasticity related gene 3), BAAT (bile acid Coenzyme A: amino acid N-acyltransferase), MRPL50 (mitochondrial ribosomal protein L50) and ZNF189 (zinc finger protein 189) genes. Centromeric to C9orf125 (chromosome 9 open reading frame 125), RNF20 (ring finger protein 20), PP3R2 (protein phosphatase 3 regulatory subunit B, beta isoform) and GRIN3A (glutamate receptor, ionotropic, N-methyl-D-aspartate 3) genes.Those genes are clustered within a genomic region at 102,830K103,540K bp of chromosome 9q. DNA/RNA
منابع مشابه
Radiation hybrid mapping of the pig ALDOA, ALDOB and ALDOC genes to SSC3, SSC1 and SSC12.
Source/description: Fructose-1, 6-bisphosphate aldolase is a glycolytic enzyme which plays a critical role in the reversible conversion of fructose-1, 6-bisphosphate to glyceraldehydes 3-phosphate and dihydroxyacetone phosphate. It is reported that in vertebrates fructose-1, 6-bisphosphate aldolase has three isozymes: aldolase A, fructose-bisphosphate (ALDOA); aldolase B, fructose-bisphosphate ...
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Background : Colorectal cancer is the third most common cancer in both sex worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a documented database of rectal cancer transcriptome (GSE354...
متن کاملA Novel Frameshift Mutation of the ALDOB Gene in a Korean Girl Presenting with Recurrent Hepatitis Diagnosed as Hereditary Fructose Intolerance
Hereditary fructose intolerance is an autosomal recessive disorder that is caused by a deficiency in fructose-1-phosphate aldolase (Aldolase B). Children can present with hypoglycemia, jaundice, elevated liver enzymes and hepatomegaly after intake of dietary fructose. Long-term intake of fructose in undiagnosed patients can result in hepatic failure or renal failure. We experienced a case of he...
متن کاملMolecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain.
Hereditary fructose intolerance (HFI) is an autosomal recessive metabolic disorder caused by aldolase (fructosediphosphate aldolase, EC 4.1.2.13) B deficiency. The B isoform of aldolase is critical for the metabolism of exogenous fructose by the liver, kidney, and intestine, since it can use fructose-1-phosphate as substrate at physiological concentrations, unlike aldolases A and C. Affected su...
متن کاملHuman aldolase B cDNA detects a Pvu II RFLP in healthy individuals
CODING SEQUENCE: Human aldolase B gene (ALDOB). The gene is a single copy and its chromosomal location is 9q21.3-q32 MENDELIAN INHERITANCE: Demonstrated in one family. The mother and the son are heterozygotes, whereas the father is a homozygote. OTHER COMMENTS: Hereditary fructose intolerance is due to a lack of aldolase B activity in liver. Although we observed no 2.3 kb homozygotes, no sign o...
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